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KS-99

CAS No. 1344698-28-7

KS-99( KS99 | KS 99 )

Catalog No. M11378 CAS No. 1344698-28-7

KS-99 (KS99) is a novel dual inhibitor of BTK and tubulin polymerization.

Purity : >98% (HPLC)

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50MG	1782	Get Quote
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Biological Information

Product Name

KS-99
Note

Research use only, not for human use.
Brief Description

KS-99 (KS99) is a novel dual inhibitor of BTK and tubulin polymerization.
Description

KS-99 (KS99) is a novel dual inhibitor of BTK and tubulin polymerization; interacts directly with the catalytic domain of BTK and inhibits phosphorylation at the Y223 residue and kinase activities; reduces the cell viability of MM and CD138+ cells (IC50=0.5-1 uM); inhibits the in vivo tumor growth of MM cells through the inhibition of BTK and tubulin.
In Vitro

——
In Vivo

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Synonyms

KS99 | KS 99
Pathway

Tyrosine Kinase
Target

BTK
Recptor

BTK
Research Area

——
Indication

——

Chemical Information

CAS Number

1344698-28-7
Formula Weight

466.147
Molecular Formula

C17H10Br2N2O2S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C1N(CC2=CC=C(CSC#N)C=C2)C3=C(C=C(Br)C=C3Br)C1=O
Chemical Name

5,7-dibromo-1-(4-(thiocyanatomethyl)benzyl)indoline-2,3-dione

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Pandey MK, et al. Exp Hematol. 2017 Jun 22. pii: S0301-472X(17)30233-3.

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