HG6-64-1( HG 6-64-1 )

Catalog No. M11274 CAS No. 1315329-43-1

COA

Datasheet

HNMR

HPLC

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Product Name

HG6-64-1
Note

Research use only, not for human use.
Brief Description

HG6-64-1 is a potent dual TAK1 and MAP4K2 ((germinal center kinase, GCK)) inhibitor with IC50 of 41 nM and 98 nM, respectively.
Description

HG6-64-1 is a potent dual TAK1 and MAP4K2 ((germinal center kinase, GCK)) inhibitor with IC50 of 41 nM and 98 nM, respectively; also inhibits ZAK, p38α, Src, Lyn, CSK and EPH-family kinases (IC50=50-100 nM); inhibits GCK signaling DLBCL cell lines with EC50 of 1.83-157 nM, induces G0/G1 cell-cycle arrest and cell death; inhibits the growth of DLBCL xenograft tumors and prolongs the survival of tumor-bearing mice.
In Vitro

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In Vivo

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Synonyms

HG 6-64-1
Pathway

MAPK/ERK Signaling
Target

MAP4K
Recptor

MAP4K
Research Area

Cancer
Indication

——

CAS Number

1315329-43-1
Formula Weight

577.6399
Molecular Formula

C32H34F3N5O2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(/C=C/C4=CN=C(NC=C5)C5=C4OC)=C3
Chemical Name

Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[(1E)-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)ethenyl]-4-methyl-

1. Tan L, et al. J Med Chem. 2015 Jan 8;58(1):183-96. 2. Matthews JM, et al. Blood. 2016 Jul 14;128(2):239-48.

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