HUHS-015( HUHS015 )

Catalog No. M11950 CAS No. 1453097-13-6

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Product Name

HUHS-015
Note

Research use only, not for human use.
Brief Description

HUHS-015 (HUHS015) is a potent, orally active prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with IC50 of 0.67 uM.
Description

HUHS-015 (HUHS015) is a potent, orally active prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with IC50 of 0.67 uM; significantly suppresses the growth of DU145 cells in vitro and in a mouse xenograft model.
In Vitro

HUHS015 significantly suppresses the growth of DU145 cells, which are human hormone-independent prostate cancer cells.
In Vivo

HUHS015 potently suppresses the growth of DU145 cells in a mouse xenograft model.HUHS015 displays 7.2% bioavailability (BA) in rats after oral administration. Animal Model:Nude miceDosage:32 mg/kg Administration:Subcutaneous injection; daily; 6 days Result:Has inhibitory effect on the growth of subcutaneously implanted DU145, without limiting weight gains after a 6 days continuous administration.
Synonyms

HUHS015
Pathway

Cell Cycle/DNA Damage
Target

DNA Repair Protein
Recptor

PCA-1/ALKBH3inhibitor
Research Area

Cancer
Indication

——

CAS Number

1453097-13-6
Formula Weight

318.3724
Molecular Formula

C19H18N4O
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 34 mg/mL
SMILES

OC1=C(CC2=CC=CC=C2)C(C)=NN1C3=NC4=CC(C)=CC=C4N3
Chemical Name

1H-Pyrazol-5-ol, 3-methyl-1-(6-methyl-1H-benzimidazol-2-yl)-4-(phenylmethyl)-

1. Nakao S, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1071-4. 2. Mabuchi M, et al. In Vivo. 2015 Jan-Feb;29(1):39-43.

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