Thioridazine hydrochloride

Research use only, not for human use.

Thioridazine is an antipsychotic drug, used in the treatment of schizophrenia and psychosis, shows D4 selectivity or serotonin antagonism.

Thioridazine is an antipsychotic drug, used in the treatment of schizophrenia and psychosis, shows D4 selectivity or serotonin antagonism.(In Vitro):Thioridazine (0.01-100 μM; 48 h) reduces the cell viability of NCI-N87 and AGS cells in a concentration-dependent manner.Thioridazine (15 μM; 24 h) reduces cell viability of the cervical (HeLa, Caski and C33A) and endometrial (HEC-1-A and KLE) cancer cells.Thioridazine (1-15 μM; 24-48 h) induces gastric cancer cell death via the mitochondrial apoptosis pathway and mitochondrial pathway.Thioridazine (15 μM; 24 h) modulates the regulation of cell cycle progression by interfering with the PI3K/Akt pathway and induces G1 cell cycle arrest in cervical and endometrial cancer cells .Thioridazine inhibits the growth of antibiotic-sensitive and multidrug-resistant strains of A. baumannii.(In Vivo):Thioridazine (25 mg/kg; i.p. every 3 days for 3 weeks) extends the survival of tumor-bearing mice and reduces the number of pluripotent embryonal carcinoma (EC) cells within tumors.Thioridazine (1.0-5.0 mg/kg; s.c.) reduces oral behavior and selectively blocks repetitive head bobbing.

Cell Proliferation Assay Cell Line:NCI-N87 and AGS cells Concentration:0.01, 0.1, 0.5, 1, 5, 10, 20, 50, 100 μM.Incubation Time:48 hours Result:Exhibited cytotoxicity in gastric cancer cells.Western Blot Analysis Cell Line:NCI-N87 and AGS cells Concentration:1, 5, 10, 15 μM Incubation Time:24, 48 hours Result:Down regulated the precursors of caspase-9, caspase-8 and caspase-3.

Animal Model:Nude and Rag2KO mice were injected with iPS cells or NT2D1 cells Dosage:25 mg/kg Administration:I.p. every 3 days for 3 weeks Result:Reduced the number of OCT4-expressing cells within malignant teratocarcinomas and extended the survival of tumor-bearing mice.With no effect on fertility.

Aldazine | Mellaril

Endocrinology/Hormones

5-HT Receptor

5-HT| Adrenergic Receptor| Dopamine| Potassium Channel

Neurological Disease

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130-61-0

407.04

C21H27ClN2S2

>98% (HPLC)

Soluble in DMSO

Cl.CSC1=CC2=C(SC3=CC=CC=C3N2CCC2CCCCN2C)C=C1

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(-20℃)

With Ice Pack

≥ 2 years