Lofepramine( Lopramine | Amplit | Leo 640 | Gamanil )

Catalog No. M26742 CAS No. 23047-25-8

Lofepramine is a potent tricyclic antidepressant that is extensively metabolized to desipramine.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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10MG	82	Get Quote
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Biological Information

Product Name

Lofepramine
Note

Research use only, not for human use.
Brief Description

Lofepramine is a potent tricyclic antidepressant that is extensively metabolized to desipramine.
Description

Lofepramine is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors.
In Vitro

——
In Vivo

——
Synonyms

Lopramine | Amplit | Leo 640 | Gamanil
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

Topo II
Research Area

——
Indication

——

Chemical Information

CAS Number

23047-25-8
Formula Weight

418.97
Molecular Formula

C26H27ClN2O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (119.34 mM)
SMILES

CN(CCCN1c2ccccc2CCc2ccccc12)CC(=O)c1ccc(Cl)cc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.J P Braybrooke, et al. A phase II study of Razoxane, an antiangiogenic topoisomerase II inhibitor, in renal cell cancer with assessment of potential surrogate markers of angiogenesis. Clin Cancer Res.2000; 6(12):4697-704.

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