TBK1-IN-1( MDK10496 | MDK10496 | MDK10496 | IKKε-IN-1 )

Catalog No. M11183 CAS No. 1292310-49-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

TBK1-IN-1
Note

Research use only, not for human use.
Brief Description

TBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor.
Description

TBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor, dose-dependently inhibits pIRF3(S386) in Panc 05.04 cells with IC50 of 1.8 nM; inhibits IRF3 nuclear translocation with IC50 of 95 nM, but does not significantly inhibits cell proliferation in some NSCLC, pancreatic, and colorectal cell lines.
In Vitro

TBK1/IKKε-IN-2 (Cmpound #1) inhibits TBK1 biochemical function in Ulight kinase assay at 5 and 250 μM ATP concentration with IC50s of0.6 and 2.6 nM, rsespectively. TBK1/IKKε-IN-2 inhibits IKKε biochemical function in Ulight kinase assay at 10 μM ATP with an IC50 of 3.9 nM. The IC50 of TBK1/IKKε-IN-2 in the Panc 02.13 proliferation assay is 5 μM.
In Vivo

——
Synonyms

MDK10496 | MDK10496 | MDK10496 | IKKε-IN-1
Pathway

Immunology/Inflammation
Target

IκB kinase (IKK)
Recptor

IκB kinase (IKK)
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1292310-49-6
Formula Weight

457.5243
Molecular Formula

C26H27N5O3
Purity

>98% (HPLC)
Solubility

DMSO: 21.5 mg/mL
SMILES

N#CC1=CC(C2=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC=C2)=CC=C1OC5CCOCC5
Chemical Name

Benzonitrile, 5-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]-

1. Muvaffak A, et al. Mol Cancer Res. 2014 Jul;12(7):1055-66.

Calculator

molnova catalog