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S1RA hydrochloride
CAS No. 1265917-14-3
S1RA hydrochloride( E-52862 hydrochloride )
Catalog No. M11114 CAS No. 1265917-14-3
A potent and selective sigma-1 receptor antagonist with Ki of 17 nM; shows excellent selectivity over sigma-2 receptor (Ki>1 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | In Stock |
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| 5MG | 80 | In Stock |
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| 10MG | 120 | In Stock |
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| 25MG | 259 | In Stock |
|
| 50MG | 405 | In Stock |
|
| 100MG | 597 | In Stock |
|
| 500MG | 1251 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameS1RA hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective sigma-1 receptor antagonist with Ki of 17 nM; shows excellent selectivity over sigma-2 receptor (Ki>1 uM).
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DescriptionA potent and selective sigma-1 receptor antagonist with Ki of 17 nM; shows excellent selectivity over sigma-2 receptor (Ki>1 uM); shows high activity in the mouse capsaicin model of neurogenic pain, exerts dose-dependent antinociceptive effects in several neuropathic pain models.Pain Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsE-52862 hydrochloride
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PathwayAutophagy
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TargetSigma receptor
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Recptorσ2|σ1R
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number1265917-14-3
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Formula Weight373.8765
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Molecular FormulaC20H24ClN3O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 57 mg/mL
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SMILESCC1=CC(=NN1C2=CC3=CC=CC=C3C=C2)OCCN4CCOCC4.Cl
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Chemical NameMorpholine, 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Díaz JL, et al. J Med Chem. 2012 Oct 11;55(19):8211-24.
2. Romero L, et al. Br J Pharmacol. 2012 Aug;166(8):2289-306.
3. Nieto FR, et al. J Pain. 2012 Nov;13(11):1107-21.
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