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S1RA
CAS No. 878141-96-9
S1RA( E-52862 )
Catalog No. M16373 CAS No. 878141-96-9
A potent and selective sigma-1 receptor antagonist with Ki of 17 nM; shows excellent selectivity over sigma-2 receptor (Ki>1 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 76 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 128 | In Stock |
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| 25MG | 215 | In Stock |
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| 50MG | 312 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameS1RA
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective sigma-1 receptor antagonist with Ki of 17 nM; shows excellent selectivity over sigma-2 receptor (Ki>1 uM).
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DescriptionA potent and selective sigma-1 receptor antagonist with Ki of 17 nM; shows excellent selectivity over sigma-2 receptor (Ki>1 uM); shows high activity in the mouse capsaicin model of neurogenic pain, exerts dose-dependent antinociceptive effects in several neuropathic pain models.Pain Phase 2 Clinical.
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In Vitro——
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In VivoAnimal Model:WT and TRPA1 KO mice with AITC (10 μl at 10 mM) in their hind paws Dosage:40 mg/kg Administration:IP; single dose; 24-h before evaluation Result:Produced a substantial reduction in pain-related responses to intradermal AITC in WT mice.
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SynonymsE-52862
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PathwayAutophagy
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TargetSigma receptor
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Recptorσ1
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number878141-96-9
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Formula Weight337.4155
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Molecular FormulaC20H23N3O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=CC(OCCN2CCOCC2)=NN1C1=CC2=CC=CC=C2C=C1
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Chemical NameMorpholine, 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Díaz JL, et al. J Med Chem. 2012 Oct 11;55(19):8211-24.
2. Romero L, et al. Br J Pharmacol. 2012 Aug;166(8):2289-306.
3. Nieto FR, et al. J Pain. 2012 Nov;13(11):1107-21.
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