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Home - Products - GPCR/G Protein - Cannabinoid Receptor - AM-6538

AM-6538

CAS No. 1245626-00-9

AM-6538( AM6538 | AM 6538 )

Catalog No. M10994 CAS No. 1245626-00-9

AM-6538 (AM6538) is a potent, selective cannabinoid receptor CB1 antagonist with Ki of 5.1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AM-6538
  • Note
    Research use only, not for human use.
  • Brief Description
    AM-6538 (AM6538) is a potent, selective cannabinoid receptor CB1 antagonist with Ki of 5.1 nM.
  • Description
    AM-6538 (AM6538) is a potent, selective cannabinoid receptor CB1 antagonist with Ki of 5.1 nM.
  • In Vitro
    AM6538 is a cannabinoid antagonist that binds CB1 receptors expressed in HEK-293 cells in a wash-resistant manner.
  • In Vivo
    AM6538 (1~10 mg/kg) antagonizes the antinociceptive effects of cannabinoid agonists in mice.AM6538 (10 mg/kg) shows that there are some recovery in the effects of AM4054. AM6538 dose dependently decreases the tau values for all cannabinoid agonists, reflecting reductions in the available receptors. AM6538 produces enduring antagonism, with robust effects on the tetrahydrocannabinol dose-effect function evident up to 7 days after treatment.
  • Synonyms
    AM6538 | AM 6538
  • Pathway
    GPCR/G Protein
  • Target
    Cannabinoid Receptor
  • Recptor
    Cannabinoid Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1245626-00-9
  • Formula Weight
    542.417
  • Molecular Formula
    C26H25Cl2N5O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 180 mg/mL (331.85 mM)
  • SMILES
    O=[N+]([O-])OCCC#CC1=CC=C(C2=C(C)C(C(NN3CCCCC3)=O)=NN2C4=CC=C(Cl)C(Cl)=C4)C=C1
  • Chemical Name
    4-(4-(1-(2,4-dichlorophenyl)-4-methyl-3-(piperidin-1-ylcarbamoyl)-1H-pyrazol-5-yl)phenyl)but-3-yn-1-yl nitrate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hua T, et al. Cell. 2016 Oct 20;167(3):750-762.e14.
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