AM-6538( AM6538 | AM 6538 )

Catalog No. M10994 CAS No. 1245626-00-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AM-6538
Note

Research use only, not for human use.
Brief Description

AM-6538 (AM6538) is a potent, selective cannabinoid receptor CB1 antagonist with Ki of 5.1 nM.
Description

AM-6538 (AM6538) is a potent, selective cannabinoid receptor CB1 antagonist with Ki of 5.1 nM.
In Vitro

AM6538 is a cannabinoid antagonist that binds CB1 receptors expressed in HEK-293 cells in a wash-resistant manner.
In Vivo

AM6538 (1~10 mg/kg) antagonizes the antinociceptive effects of cannabinoid agonists in mice.AM6538 (10 mg/kg) shows that there are some recovery in the effects of AM4054. AM6538 dose dependently decreases the tau values for all cannabinoid agonists, reflecting reductions in the available receptors. AM6538 produces enduring antagonism, with robust effects on the tetrahydrocannabinol dose-effect function evident up to 7 days after treatment.
Synonyms

AM6538 | AM 6538
Pathway

GPCR/G Protein
Target

Cannabinoid Receptor
Recptor

Cannabinoid Receptor
Research Area

——
Indication

——

CAS Number

1245626-00-9
Formula Weight

542.417
Molecular Formula

C26H25Cl2N5O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 180 mg/mL (331.85 mM)
SMILES

O=[N+]([O-])OCCC#CC1=CC=C(C2=C(C)C(C(NN3CCCCC3)=O)=NN2C4=CC=C(Cl)C(Cl)=C4)C=C1
Chemical Name

4-(4-(1-(2,4-dichlorophenyl)-4-methyl-3-(piperidin-1-ylcarbamoyl)-1H-pyrazol-5-yl)phenyl)but-3-yn-1-yl nitrate

1. Hua T, et al. Cell. 2016 Oct 20;167(3):750-762.e14.

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