Cart
sales@molnova.com
CB2R/FAAH?modulator-2
CAS No. 2876918-68-0
CB2R/FAAH?modulator-2( —— )
Catalog No. M35953 CAS No. 2876918-68-0
CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting CB2R and FAAH, acting as a CB2R agonist (Ki = 10.8 nM) and FAAH inhibitor (IC50 = 6.2 μM), with a Ki value of 152.9 nM for CB1R.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 82 | In Stock |
|
| 5MG | 68 | In Stock |
|
| 10MG | 116 | In Stock |
|
| 25MG | 188 | In Stock |
|
| 50MG | 276 | In Stock |
|
| 100MG | 421 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCB2R/FAAH?modulator-2
-
NoteResearch use only, not for human use.
-
Brief DescriptionCB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting CB2R and FAAH, acting as a CB2R agonist (Ki = 10.8 nM) and FAAH inhibitor (IC50 = 6.2 μM), with a Ki value of 152.9 nM for CB1R.
-
DescriptionCB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.
-
In VitroCB2R/FAAH modulator-2 (compound 26)(10 μM) reduces the production of the pro-inflammatory cytokines TNFα, IFN-γ, IL-1β and IL6 in unstimulated monocytes and macrophages.
-
In Vivo——
-
Synonyms——
-
PathwayGPCR/G Protein
-
TargetCannabinoid Receptor
-
RecptorCannabinoid Receptor | FAAH
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2876918-68-0
-
Formula Weight367.52
-
Molecular FormulaC24H33NO2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESN(C(=O)C1=C(OCC2CCCCC2)C=CC=C1)C34CC5CC(C3)CC(C4)C5
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Francesca Intranuovo, et al. Development of?N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66(1):235-250.?
molnova catalog
related products
-
CB2R PAM
CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists.
-
GW 833972A
GW 833972A is a selective CB2 receptor agonist that inhibits induced neural depolarization and citric acid-induced cough in an animal model.
-
GW 405833
GW 405833 is an agonist of cannabinoid-2 (CB(2)) receptor-selective.
