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CB2R/FAAH?modulator-2
CAS No. 2876918-68-0
CB2R/FAAH?modulator-2( —— )
Catalog No. M35953 CAS No. 2876918-68-0
CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting CB2R and FAAH, acting as a CB2R agonist (Ki = 10.8 nM) and FAAH inhibitor (IC50 = 6.2 μM), with a Ki value of 152.9 nM for CB1R.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 82 | In Stock |
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| 5MG | 68 | In Stock |
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| 10MG | 116 | In Stock |
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| 25MG | 188 | In Stock |
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| 50MG | 276 | In Stock |
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| 100MG | 421 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCB2R/FAAH?modulator-2
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NoteResearch use only, not for human use.
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Brief DescriptionCB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting CB2R and FAAH, acting as a CB2R agonist (Ki = 10.8 nM) and FAAH inhibitor (IC50 = 6.2 μM), with a Ki value of 152.9 nM for CB1R.
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DescriptionCB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.
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In VitroCB2R/FAAH modulator-2 (compound 26)(10 μM) reduces the production of the pro-inflammatory cytokines TNFα, IFN-γ, IL-1β and IL6 in unstimulated monocytes and macrophages.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetCannabinoid Receptor
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RecptorCannabinoid Receptor | FAAH
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Research Area——
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Indication——
Chemical Information
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CAS Number2876918-68-0
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Formula Weight367.52
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Molecular FormulaC24H33NO2
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Purity>98% (HPLC)
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Solubility——
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SMILESN(C(=O)C1=C(OCC2CCCCC2)C=CC=C1)C34CC5CC(C3)CC(C4)C5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Francesca Intranuovo, et al. Development of?N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66(1):235-250.?
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