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APY0201
CAS No. 1232221-74-7
APY0201( APY0201 | APY-0201 | APY 0201 )
Catalog No. M10917 CAS No. 1232221-74-7
APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC50=5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 64 | In Stock |
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| 5MG | 98 | In Stock |
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| 10MG | 173 | In Stock |
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| 25MG | 312 | In Stock |
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| 50MG | 530 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
| 2MG | 67 | In Stock |
|
| 5MG | 104 | In Stock |
|
| 10MG | 182 | In Stock |
|
| 25MG | 330 | In Stock |
|
| 50MG | 548 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAPY0201
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NoteResearch use only, not for human use.
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Brief DescriptionAPY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC50=5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2.
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DescriptionAPY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC50=5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2; a unique small molecular IL-12/23 production inhibitor.
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In Vitro——
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In Vivo——
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SynonymsAPY0201 | APY-0201 | APY 0201
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPIKfyve
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1232221-74-7
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Formula Weight413.48
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Molecular FormulaC23H23N7O
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESCC1=CC(/C=N/NC2=NC3=CC(C4=CC=NC=C4)=NN3C(N5CCOCC5)=C2)=CC=C1
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Chemical Name(E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hayakawa N, et al. Bioorg Med Chem. 2014 Jun 1;22(11):3021-9.
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