Cart
sales@molnova.com
ML324
CAS No. 1222800-79-4
ML324( ML-324 )
Catalog No. M10846 CAS No. 1222800-79-4
ML324 is a potent, selective JMJD2 demethylase (KDM4) inhibitor with IC50 of 920 nM for JMJD2E.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
|
| 10MG | 65 | In Stock |
|
| 25MG | 117 | In Stock |
|
| 50MG | 209 | In Stock |
|
| 100MG | 375 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameML324
-
NoteResearch use only, not for human use.
-
Brief DescriptionML324 is a potent, selective JMJD2 demethylase (KDM4) inhibitor with IC50 of 920 nM for JMJD2E.
-
DescriptionML324 is a potent, selective JMJD2 demethylase (KDM4) inhibitor with IC50 of 920 nM for JMJD2E, shows no activity against LSD1 (>100-fold selectivity); causes depression-like phenotype even in absence of stress exposure, which is associated with an increase in transcriptionally repressive epigenetic marks H3K9me2/me3 in nucleus accumbens (NAc); blocks TNF-α-mediated neutrophil adhesion, reduces TNF-α-induced ICAM1 protein expression in cerebral microvessels.
-
In VitroML324 produces a significant reduction in Aa-LPS-induced osteoclastogenesis in osteoclast progenitors.
-
In Vivo——
-
SynonymsML-324
-
PathwayChromatin/Epigenetic
-
TargetHistone Demethylase
-
RecptorJMJD2
-
Research AreaInfection
-
Indication——
Chemical Information
-
CAS Number1222800-79-4
-
Formula Weight349.4262
-
Molecular FormulaC21H23N3O2
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 33 mg/mL
-
SMILESO=C(NCCCN(C)C)C1=CC=C(C2=CC(O)=C3N=CC=CC3=C2)C=C1
-
Chemical NameBenzamide, N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Rai G, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. Pathak SS, et al. Neuropsychopharmacology. 2017 Mar;42(4):854-863.
3. Choi JY, et al. Sci Rep. 2017 Mar 22;7:45005.
4. Ishiguro K, et al. Clin Immunol. 2017 Jul;180:120-127.
molnova catalog
related products
-
LSD1-IN-30
LSD1-IN-30 is a lysine-specific demethylase 1 (LSD1) inhibitor with anticancer activity for the study of small cell lung cancer and acute myeloid leukemia.
-
SD-70
A small molecule tumor translocation inhibitor that inhibits the prostate cancer cell transcriptional program.
-
SETDB1-TTD-IN-1
SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SETDB1-TTD with a Kd of 88 nM.
