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Tazemetostat hydrobromide
CAS No. 1467052-75-0
Tazemetostat hydrobromide( EPZ-6438 hydrobromide | E-7438 hydrobromide )
Catalog No. M26837 CAS No. 1467052-75-0
Tazemetostat hydrobromide is a potent and selective EZH2 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 72 | In Stock |
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| 2MG | 34 | In Stock |
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| 5MG | 52 | In Stock |
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| 10MG | 70 | In Stock |
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| 50MG | 90 | In Stock |
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| 100MG | 151 | In Stock |
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| 200MG | 226 | In Stock |
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| 500MG | 369 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTazemetostat hydrobromide
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NoteResearch use only, not for human use.
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Brief DescriptionTazemetostat hydrobromide is a potent and selective EZH2 inhibitor.
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DescriptionTazemetostat hydrobromide is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki: 2.5 nM). Tazemetostat hydrobromide also inhibits EZH1 (IC50: 392 nM).(In Vitro):Tazemetostat hydrobromide inhibits Rat EZH2 (IC50: 4 nM). Tazemetostat hydrobromide inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat hydrobromide inhibits multi wild-type and mutant lymphoma cell lines proliferation with IC50s of 0.49 nM-7.6 μM .(In Vivo):Tazemetostat (250 or 500 mg/kg twice daily for 21-28 days) practically eliminates the fast-growing G401 tumors .
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In Vitro——
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In Vivo——
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SynonymsEPZ-6438 hydrobromide | E-7438 hydrobromide
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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Recptormicrotubule
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Research Area——
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Indication——
Chemical Information
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CAS Number1467052-75-0
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Formula Weight653.662
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Molecular FormulaC34H45BrN4O4
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Purity>98% (HPLC)
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Solubility——
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SMILESBr.CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ekaterina Poluektova, et al. Curvulin and Phaeosphaeride A From Paraphoma Sp. VIZR 1.46 Isolated From Cirsium arvense as Potential Herbicides. Molecules. 2018 Oct 28;23(11):2795.
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