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PF-46396

CAS No. 1207481-21-7

PF-46396( PF 46396 | PF46396 )

Catalog No. M10767 CAS No. 1207481-21-7

PF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-46396
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein.
  • Description
    PF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein; exhibits antiviral activity against 17/27 HIV-1 clinical isolates with EC50s ranging from 0.005 to 7 uM and TI values ranging from 2 to 3,400.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PF 46396 | PF46396
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1207481-21-7
  • Formula Weight
    454.537
  • Molecular Formula
    C27H29F3N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C(C(F)(F)F)=CC=CN1CC(C2=CC=C(C(C)(C)C)C=C2)NC3CC4=C(C=CC=C4)C3
  • Chemical Name
    1-[2-(4-tert-butylphenyl)-2-(2,3-dihydro-1H-inden-2-ylamino)ethyl]-3-(trifluoromethyl)pyridin-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Blair WS, et al. Antimicrob Agents Chemother. 2009 Dec;53(12):5080-7. 2. Murgatroyd C, et al. J Virol. 2016 Aug 26;90(18):8181-97. 3. Waki K, et al. PLoS Pathog. 2012;8(11):e1002997.
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