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PF-46396
CAS No. 1207481-21-7
PF-46396( PF 46396 | PF46396 )
Catalog No. M10767 CAS No. 1207481-21-7
PF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePF-46396
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NoteResearch use only, not for human use.
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Brief DescriptionPF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein.
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DescriptionPF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein; exhibits antiviral activity against 17/27 HIV-1 clinical isolates with EC50s ranging from 0.005 to 7 uM and TI values ranging from 2 to 3,400.
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In Vitro——
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In Vivo——
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SynonymsPF 46396 | PF46396
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research Area——
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Indication——
Chemical Information
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CAS Number1207481-21-7
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Formula Weight454.537
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Molecular FormulaC27H29F3N2O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C(C(F)(F)F)=CC=CN1CC(C2=CC=C(C(C)(C)C)C=C2)NC3CC4=C(C=CC=C4)C3
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Chemical Name1-[2-(4-tert-butylphenyl)-2-(2,3-dihydro-1H-inden-2-ylamino)ethyl]-3-(trifluoromethyl)pyridin-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Blair WS, et al. Antimicrob Agents Chemother. 2009 Dec;53(12):5080-7.
2. Murgatroyd C, et al. J Virol. 2016 Aug 26;90(18):8181-97.
3. Waki K, et al. PLoS Pathog. 2012;8(11):e1002997.
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