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GNE-900
CAS No. 1200126-26-6
GNE-900( GNE 900 | GNE900 )
Catalog No. M10717 CAS No. 1200126-26-6
GNE-900 (GNE900) is a potent, selective, ATP-competitive, and orally bioavailable Chk1 inhibitor with IC50 of <1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 92 | In Stock |
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| 10MG | 148 | In Stock |
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| 25MG | 263 | In Stock |
|
| 50MG | 388 | In Stock |
|
| 100MG | 594 | In Stock |
|
| 200MG | 812 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGNE-900
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NoteResearch use only, not for human use.
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Brief DescriptionGNE-900 (GNE900) is a potent, selective, ATP-competitive, and orally bioavailable Chk1 inhibitor with IC50 of <1 nM.
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DescriptionGNE-900 (GNE900) is a potent, selective, ATP-competitive, and orally bioavailable Chk1 inhibitor with IC50 of <1 nM; displays >300-fold selectivity over Aurora, PLK, CDK1/2) and ChK2; abrogates DNA damage-induced S and G2–M checkpoints (EC50=61.8 nM in H-29 cells), and exacerbates DNA double-strand breaks (DSB) to induce cell death, accelerates the demise of damaged HCT-116 colorectal cancer cells in a p53-dependent manner in vitro; potentiates the efficacy of gemcitabine in tumor xenografts.
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In Vitro——
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In VivoAnimal Model:Sprague-Dawley rats (HT-29 tumor xenografts)Dosage:2.5-40 mg/kg (received a dose of gemcitabine 120 mg/kg)Administration:P.o.; once Result:Decreased the tumor volume and resulted in significant enhancement of DNA damage, increased γ-H2AX levels.
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SynonymsGNE 900 | GNE900
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PathwayAngiogenesis
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TargetChk
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RecptorChk
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Research Area——
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Indication——
Chemical Information
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CAS Number1200126-26-6
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Formula Weight367.45
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Molecular FormulaC23H21N5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (272.15 mM)
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SMILESN#CC1=NC=C2C(C3=CC(C4=CC=C(CN5CCCCC5)C=C4)=CN=C3N2)=C1
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Chemical Name3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Blackwood E, et al. Mol Cancer Ther. 2013 Oct;12(10):1968-80.
2. Xiao Y, et al. Mol Cancer Ther. 2013 Nov;12(11):2285-95.
3. Gazzard L, et al. J Med Chem. 2015 Jun 25;58(12):5053-74.
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