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MK 8776
CAS No. 891494-63-6
MK 8776( SCH 900776 )
Catalog No. M16431 CAS No. 891494-63-6
MK 8776 (SCH 900776) is a potent and functionally selective CHK1 inhibitor (IC50=3 nM) with minimal intrinsic antagonistic properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 81 | In Stock |
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| 5MG | 74 | In Stock |
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| 10MG | 144 | In Stock |
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| 25MG | 282 | In Stock |
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| 50MG | 452 | In Stock |
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| 100MG | 646 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMK 8776
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NoteResearch use only, not for human use.
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Brief DescriptionMK 8776 (SCH 900776) is a potent and functionally selective CHK1 inhibitor (IC50=3 nM) with minimal intrinsic antagonistic properties.
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DescriptionMK 8776 (SCH 900776) is a potent and functionally selective CHK1 inhibitor (IC50=3 nM) with minimal intrinsic antagonistic properties; also inhibits CDK2 with IC50 of 160 nM, weak activity for CHK2 and no significant inhibition of cytochrome P450 isoforms; induces dose-dependent suppression of CHK1 pS296 and concomitant accumulation of phospho-RPA signal in U2OS cells; interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce dsDNA breaks and cell death in the A2780 xenograft model.Blood Cancer Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsSCH 900776
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PathwayAngiogenesis
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TargetChk
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RecptorCDK2|Chk1|Chk2
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number891494-63-6
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Formula Weight376.25
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Molecular FormulaC15H18BrN7
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Purity>98% (HPLC)
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SolubilityDMSO: 3 mg/mL (7.97 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESNC1=C(Br)C([C@H]2CNCCC2)=NC3=C(C4=CN(C)N=C4)C=NN13
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Chemical Name6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinyl-pyrazolo[1,5-a]pyrimidin-7-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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SAR-020106
SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3 nmol/L on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion.
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CCT-244747
A novel, potent, highly selective, orally active, ATP competitive CHK1 inhibitor with biochemical IC50 of 8 nM; displays 75-fold selectivity against FLT3 and >1,000-fold selectivity against CHK2 and CDK1.
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GDC-0575
GDC-0575 (ARRY-575, RG-7741)?is a potent, selective and orally bioavailable Chk1 inhibitor with IC50 of 1.2 nM.
