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Ecteinascidin 770
CAS No. 114899-80-8
Ecteinascidin 770( Ecteinascidine 770 | Et 770 | Et-770 | Et770 )
Catalog No. M10526 CAS No. 114899-80-8
A tetrahydroisoquinoline alkaloid with potent anticaner activities; shows cytotoxicity against human cell lines HCT116, QG56, and DU145 with IC50 of 0.60, 2.4, and 0.81 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 582 | In Stock |
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| 5MG | 465 | In Stock |
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| 10MG | 687 | In Stock |
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| 25MG | 1064 | In Stock |
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| 50MG | 1414 | In Stock |
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| 100MG | 1832 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameEcteinascidin 770
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NoteResearch use only, not for human use.
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Brief DescriptionA tetrahydroisoquinoline alkaloid with potent anticaner activities; shows cytotoxicity against human cell lines HCT116, QG56, and DU145 with IC50 of 0.60, 2.4, and 0.81 nM, respectively.
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DescriptionA tetrahydroisoquinoline alkaloid with potent anticaner activities; shows cytotoxicity against human cell lines HCT116, QG56, and DU145 with IC50 of 0.60, 2.4, and 0.81 nM, respectively; sensitizes H23 the cells by activating the p53 protein, down-regulates MCL1 and up-regulates BAX proteins, with no effect on Bcl-2; enhances anoikis response of human lung cancer H23 and H460 cells.
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In VitroEcteinascidin 770 induces apoptosis of U373MG cells. The IC50 concentration of ecteinascidin 770 for killing U373MG glioblastoma cells in culture by using the MTT assay is 4.83 nM by a 72 hour-treatment. The IC50 values against human cell lines HCT116, QG56, and DU145 are 0.6, 2.4, and 0.81 nM, respectively. ET-770 is shown to enhance anoikis response of human lung cancer H23 cells in a dose-dependent manner. Ecteinascidin 770 sensitizes the cells by activating the p53 protein, which in turn down-regulates anti-apoptotic myeloid cell leukemia sequence-1 (MCL1) and up-regulates BCL2-associated X protein (BAX) proteins. However, B-cell lymphoma-2 (BCL2) proteins are not significantly affected by Ecteinascidin 770. The anoikis sensitization of ET-770 is observed in H460 lung cancer cells.
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In Vivo——
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SynonymsEcteinascidine 770 | Et 770 | Et-770 | Et770
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number114899-80-8
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Formula Weight770.84728
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Molecular FormulaC40H42N4O10S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=CC2=C(C3C4C5C6=C(C(=C7C(=C6C(N4C(C(C2)N3C)C#N)COC(=O)C8(CS5)C9=CC(=C(C=C9CCN8)O)OC)OCO7)C)OC(=O)C)C(=C1OC)O
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Chemical NameSpiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile, 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-, (1'R,6R,6aR,
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Saktrakulkla P, et al. Bioorg Med Chem. 2011 Aug 1;19(15):4421-36.
2. Powan P, et al. Anticancer Res. 2013 Feb;33(2):505-12.
3. Puthongking P, et al. Chem Pharm Bull (Tokyo). 2006 Jul;54(7):1010-6.
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