Necrox-5 methanesulfonate( Necrosis inhibitor 5 )

Catalog No. M11590 CAS No. 1383718-29-3

NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter.

Purity : >98% (HPLC)

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Biological Information

Product Name

Necrox-5 methanesulfonate
Note

Research use only, not for human use.
Brief Description

NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter.
Description

NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter; improves mitochondrial oxygen consumption, and suppresses mitochondrial Ca(2+) overload during reoxygenation in an in vitro rat heart HR model, reduces the ouabain- or histamine-induced increase in mitochondrial Ca(2+).
In Vitro

NecroX-5 (10 or 40 μM) inhibits breast cancer cell migration, which is correlated with mitoROS reduction, and mediated by AKT inhibition. NecroX-5 (10 μM) decreases intracellular calcium concentration in 4T1 cells by blocking Ca2+ influx, which mediated the inhibition of cell migration, AKT downregulation and the reduction of mitochondrial ROS levels. NecroX-5 (10 μM) treatment for 24 h, effectively decreases the increased TNFα, TGFβ1, pSmad2 and the expression of Dcn in LPS-stimulated H9C2 cells.
In Vivo

NecroX-5 (2.5 mg/kg, everyday other day) inhibits breast cancer cell metastasis in TUBO-P2J tumour-bearing mice.
Synonyms

Necrosis inhibitor 5
Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis
Research Area

Inflammation/Immunology
Indication

——

Chemical Information

CAS Number

1383718-29-3
Formula Weight

645.801
Molecular Formula

C27H39N3O9S3
Purity

>98% (HPLC)
Solubility

DMSO : 170 mg/mL 263.24 mM
SMILES

CS(=O)(=O)O.CS(=O)(=O)O.C1COCCC1CNC2=CC(=CC3=C2NC(=C3)C4=CC=CC=C4)CN5CCS(=O)(=O)CC5
Chemical Name

5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-7-amine, dimethanesulfonate

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Thu VT, et al. Cardiovasc Res. 2012 May 1;94(2):342-50. 2. Li X, et al. Allergy. 2016 Feb;71(2):198-209. 3. Park JH, et al. Int J Oncol. 2017 Jan;50(1):185-192. 4. Thu VT, et al. Korean J Physiol Pharmacol. 2016 Mar;20(2):201-11.

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