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Necrox-5 methanesulfonate
CAS No. 1383718-29-3
Necrox-5 methanesulfonate( Necrosis inhibitor 5 )
Catalog No. M11590 CAS No. 1383718-29-3
NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 153 | In Stock |
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| 2MG | 64 | In Stock |
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| 5MG | 107 | In Stock |
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| 10MG | 155 | In Stock |
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| 25MG | 249 | In Stock |
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| 50MG | 345 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNecrox-5 methanesulfonate
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NoteResearch use only, not for human use.
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Brief DescriptionNecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter.
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DescriptionNecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter; improves mitochondrial oxygen consumption, and suppresses mitochondrial Ca(2+) overload during reoxygenation in an in vitro rat heart HR model, reduces the ouabain- or histamine-induced increase in mitochondrial Ca(2+).
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In VitroNecroX-5 (10 or 40 μM) inhibits breast cancer cell migration, which is correlated with mitoROS reduction, and mediated by AKT inhibition. NecroX-5 (10 μM) decreases intracellular calcium concentration in 4T1 cells by blocking Ca2+ influx, which mediated the inhibition of cell migration, AKT downregulation and the reduction of mitochondrial ROS levels. NecroX-5 (10 μM) treatment for 24 h, effectively decreases the increased TNFα, TGFβ1, pSmad2 and the expression of Dcn in LPS-stimulated H9C2 cells.
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In VivoNecroX-5 (2.5 mg/kg, everyday other day) inhibits breast cancer cell metastasis in TUBO-P2J tumour-bearing mice.
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SynonymsNecrosis inhibitor 5
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1383718-29-3
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Formula Weight645.801
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Molecular FormulaC27H39N3O9S3
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Purity>98% (HPLC)
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SolubilityDMSO : 170 mg/mL 263.24 mM
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SMILESCS(=O)(=O)O.CS(=O)(=O)O.C1COCCC1CNC2=CC(=CC3=C2NC(=C3)C4=CC=CC=C4)CN5CCS(=O)(=O)CC5
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Chemical Name5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-7-amine, dimethanesulfonate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Thu VT, et al. Cardiovasc Res. 2012 May 1;94(2):342-50.
2. Li X, et al. Allergy. 2016 Feb;71(2):198-209.
3. Park JH, et al. Int J Oncol. 2017 Jan;50(1):185-192.
4. Thu VT, et al. Korean J Physiol Pharmacol. 2016 Mar;20(2):201-11.
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