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Amlodipine Besylate
CAS No. 111470-99-6
Amlodipine Besylate( Amlodipine besylate | Cardiorex | Cordarene )
Catalog No. M10421 CAS No. 111470-99-6
Amlodipine Besylate is a long-acting calcium channel blocker.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 35 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 31 | In Stock |
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| 1G | 47 | In Stock |
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Biological Information
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Product NameAmlodipine Besylate
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NoteResearch use only, not for human use.
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Brief DescriptionAmlodipine Besylate is a long-acting calcium channel blocker.
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DescriptionAmlodipine Besylate is a long-acting calcium channel blocker.(In Vitro):Amlodipine besylate (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% at concentrations of 20 and 30 μM in A431 cells, respectively.Amlodipine besylate (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells.Amlodipine besylate (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells.(In Vivo):Amlodipine besylate (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice.Amlodipine besylate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice.
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In VitroAmlodipine besylate (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% at concentrations of 20 and 30 μM in A431 cells, respectively.Amlodipine besylate (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells.Amlodipine besylate (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells.
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In VivoAmlodipine besylate (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice.Amlodipine besylate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice. Animal Model:ATP2B1loxP/loxP mice Dosage:5 mg/kg/day Administration: Subcutaneously implanted osmotic pump for 2 weeks Result:Significantly decreased the blood pressure.
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SynonymsAmlodipine besylate | Cardiorex | Cordarene
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number111470-99-6
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Formula Weight567.05
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Molecular FormulaC26H31ClN2O8S
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Purity>98% (HPLC)
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SolubilityEthanol: 14 mg/mL (24.68 mM); DMSO: 113 mg/mL (199.27 mM)
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SMILESO=C(C1=C(COCCN)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Cl)OCC.O=S(C3=CC=CC=C3)(O)=O
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Chemical Name3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, monobenzenesulfonate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Cis-22a
Cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.
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Yangambin
Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibition the Ca2+ influx through voltage-gated Ca2+ channels. Yangambin has central nervous system activity, it presents a depressant activity in the open field, forced swimming and pentobarbital sleeping time tests.
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YM-244769
YM-244769 is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 has efficient protective effects on neurons and kidneys.
