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Ginsenoside-Rf

CAS No. 52286-58-5

Ginsenoside-Rf( Panaxoside Rf )

Catalog No. M21460 CAS No. 52286-58-5

Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Ginsenoside-Rf
  • Note
    Research use only, not for human use.
  • Brief Description
    Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.
  • Description
    Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.
  • In Vitro
    Ginsenoside Rf is a saponin, which is present in only trace amounts within ginseng. At saturating concentrations, Ginsenoside Rf rapidly and reversibly inhibits N-type, and other high-threshold, Ca2+ channels in rat sensory neurons to the same degree as a maximal dose of opioids. The effect is dose-dependent (half-maximal inhibition: 40 μM) and it is virtually eliminated by pretreatment of the neurons with pertussis toxin, an inhibitor of G(o) and Gi GTP-binding proteins. Ginsenoside Rf also inhibits Ca2+ channels in the hybrid F-11 cell line.
  • In Vivo
    Since inhibition of Ca2+ channels in sensory neurons contributes to antinociception by opioids, analgesic actions of Ginsenoside Rf are tested. Dose-dependent antinociception is found by systemic administration of Ginsenoside Rf in mice using two separate assays of tonic pain: in the acetic acid abdominal constriction test, the ED50 is 56±9 mg/kg, a concentration similar to those reported for aspirin and acetaminophen in the same assay; in the tonic phase of the biphasic formalin test, the ED50 is 129±32 mg/kg.
  • Synonyms
    Panaxoside Rf
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    N-type Ca2+ channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    52286-58-5
  • Formula Weight
    801.01
  • Molecular Formula
    C42H72O14
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol:5 mg/mL (62.42 mM)
  • SMILES
    [H][C@@]1(CC[C@]2(C)[C@]1([H])[C@H](O)CC1[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])[C@H](C[C@@]21C)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@@](C)(O)CC\C=C(\C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nah SY et al. A trace component of ginseng that inhibits Ca
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