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Efonidipine

CAS No. 111011-63-3

Efonidipine( NZ-105 | (±)-Efonidipine )

Catalog No. M10409 CAS No. 111011-63-3

Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 48 In Stock
5MG 33 In Stock
10MG 55 In Stock
25MG 106 In Stock
50MG 166 In Stock
100MG 269 In Stock
200MG 403 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Efonidipine
  • Note
    Research use only, not for human use.
  • Brief Description
    Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker.
  • Description
    Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker, exhibits antihypertensive effect through vasodilatation; increases coronary blood flow by blocking L & T-type calcium channels and attenuates myocardial ischaemia, lowers blood pressure in cerebral resistance vessels and prevents hypertension induced brain damage; increases glomerular filtration rate without increasing intra-glomerular pressure and filtration fraction.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NZ-105 | (±)-Efonidipine
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    CalciumChannel
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    111011-63-3
  • Formula Weight
    631.6552
  • Molecular Formula
    C34H38N3O7P
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C1=C(C)NC(C)=C(P2(OCC(C)(C)CO2)=O)C1C3=CC=CC([N+]([O-])=O)=C3)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5
  • Chemical Name
    3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Masuda Y, et al. Arch Int Pharmacodyn Ther. 1990 Mar-Apr;304:247-64. 2. Tamura T, et al. Naunyn Schmiedebergs Arch Pharmacol. 1991 Apr;343(4):405-10. 3. Shudo C, et al. Gen Pharmacol. 1994 Nov;25(7):1451-8. 4. Yamashita T, et al. Jpn J Pharmacol. 1991 Nov;57(3):337-48.
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