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BIX02188 (c)

CAS No. 1094614-84-2

BIX02188 (c)( —— )

Catalog No. M10367 CAS No. 1094614-84-2

BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM.

Purity : >98% (HPLC)

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25MG	327	In Stock
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Biological Information

Product Name

BIX02188 (c)
Note

Research use only, not for human use.
Brief Description

BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM.
Description

BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

ERK
Recptor

ERK5| MEK1| MEK2| MEK5| TGFβR1
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

1094614-84-2
Formula Weight

412.48
Molecular Formula

C25H24N4O2
Purity

>98% (HPLC)
Solubility

DMSO: 100 mM
SMILES

CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N)NC2=O)/C4=CC=CC=C4
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Tatake RJ, et al. Biochem Biophys Res Commun, 2008, 377(1), 120-125.

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