MK-4074 sodium salt( —— )

Catalog No. M10201 CAS No. 1039758-18-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MK-4074 sodium salt
Note

Research use only, not for human use.
Brief Description

MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM.
Description

MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM; lowers lipogenesis, increases ketones and reduces liver triglycerides, increases plasma triglycerides in mice; significantly decreases de novo lipogenesis (DNL) in a dose-dependent manner with ID50 of 0.9 mg/kg in models of obesity, type 2 diabetes and fatty liver.Steatohepatitis Phase 1 Clinical.
In Vitro

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In Vivo

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Synonyms

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Pathway

Metabolic Enzyme/Protease
Target

ACC
Recptor

ACC
Research Area

Other Indications
Indication

Steatohepatitis

CAS Number

1039758-18-3
Formula Weight

587.608
Molecular Formula

C33H30N3NaO6
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

5-(1'-(1-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carbonyl)-4-oxospiro[chromane-2,4'-piperidin]-6-yl)nicotinic acid, sodium salt

1. Kim CW, et al. Cell Metab. 2017 Aug 1;26(2):394-406.e6.

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