Cart
sales@molnova.com
TOFA
CAS No. 54857-86-2
TOFA( RMI14514 | MDL14514 )
Catalog No. M14977 CAS No. 54857-86-2
TOFA (RMI14514, MDL14514) is an indirect, allosteric inhibitor of Acetyl-CoA carboxylase-α (ACCA) and fatty acid synthesis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
|
| 5MG | 29 | In Stock |
|
| 10MG | 48 | In Stock |
|
| 25MG | 105 | In Stock |
|
| 50MG | 174 | In Stock |
|
| 100MG | 299 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTOFA
-
NoteResearch use only, not for human use.
-
Brief DescriptionTOFA (RMI14514, MDL14514) is an indirect, allosteric inhibitor of Acetyl-CoA carboxylase-α (ACCA) and fatty acid synthesis.
-
DescriptionTOFA (RMI14514, MDL14514) is an indirect, allosteric inhibitor of Acetyl-CoA carboxylase-α (ACCA) and fatty acid synthesis; converted to TOFyl-CoA, exerts an allosteric inhibition on ACCA; lowers blood lipids and inhibits fatty acid synthesis with minimal effects on liver weight and liver fat content; also induces human cancer cell apoptosis through disturbing their fatty acid synthesis.
-
In Vitro——
-
In Vivo——
-
SynonymsRMI14514 | MDL14514
-
PathwayMetabolic Enzyme/Protease
-
TargetACC
-
RecptorACC1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number54857-86-2
-
Formula Weight324.45498
-
Molecular FormulaC19H32O4
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 34 mg/mL
-
SMILESCCCCCCCCCCCCCCOC1=CC=C(O1)C(=O)O
-
Chemical Name2-Furancarboxylic acid, 5-(tetradecyloxy)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Parker RA, et al. J Med Chem. 1977 Jun;20(6):781-91.
2. McCune SA, et al. J Biol Chem. 1979 Oct 25;254(20):10095-101.
3. Wang C, et al. Biochem Biophys Res Commun. 2009 Jul 31;385(3):302-6.
molnova catalog
related products
-
Firsocostat
Firsocostat (ND-630, NDI-010976, GS-0976) is a highly potent, selective inhibitor of acetyl-CoA carboxylase (ACC) with IC50 of 2.1 and 6.1 nM for isozymes ACC1 and ACC2, respectively.
-
PF-05175157
PF-05175157 (PF-5175157) is a potennt Acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 27 and 33 nM for hAAC1 and hACC2, respectively.
-
Tralkoxydim
Tralkoxydim is an alkyl ketone herbicide. Tralkoxydim works as an ACCase inhibitor.
