Cart
sales@molnova.com
LM11A-31
CAS No. 102562-74-3
LM11A-31( LM11A 31 )
Catalog No. M10118 CAS No. 102562-74-3
An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameLM11A-31
-
NoteResearch use only, not for human use.
-
Brief DescriptionAn orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors.
-
DescriptionAn orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors; shows no effect on nerve growth factor (NGF) binding to TrkA; prevents and reverses atrophy of cholinergic neurites, as well as reversing AD pathologies in mid- to late-stage AD mice models.Alzheimer Disease Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsLM11A 31
-
PathwayTyrosine Kinase
-
TargetTrk Receptor
-
RecptorTrk Receptor
-
Research AreaNeurological Disease
-
IndicationAlzheimer Disease
Chemical Information
-
CAS Number102562-74-3
-
Formula Weight243.351
-
Molecular FormulaC12H25N3O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Massa SM, et al. J Neurosci. 2006 May 17;26(20):5288-300.
2. Meeker RB, et al. J Neuroimmune Pharmacol. 2012 Jun;7(2):388-400.
3. Simmons DA, et al. PLoS One. 2014 Aug 25;9(8):e102136.
4. Meeker RB, et al. Exp Neurol. 2016 Jan;275 Pt 1:182-98.
molnova catalog
related products
-
ALE-0540
ALE-0540 is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively.
-
Belizatinib
A potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM.
-
PF-06273340
PF-06273340 is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively.
