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Belizatinib
CAS No. 1357920-84-3
Belizatinib( TSR-011 | TSR011 )
Catalog No. M11469 CAS No. 1357920-84-3
A potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 47 | In Stock |
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| 5MG | 80 | In Stock |
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| 10MG | 129 | In Stock |
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| 25MG | 259 | In Stock |
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| 50MG | 357 | In Stock |
|
| 100MG | 500 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBelizatinib
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM.
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DescriptionA potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM; exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.Blood Cancer Phase 2 Clinical(In Vitro):TSR-011 has antitumour activity in the clinical trials.(In Vivo):TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.
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In VitroTSR-011 has antitumour activity in the clinical trials.
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In VivoTSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.
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SynonymsTSR-011 | TSR011
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PathwayTyrosine Kinase
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TargetTrk Receptor
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RecptorALK
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1357920-84-3
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Formula Weight577.745
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Molecular FormulaC33H44FN5O3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥300 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C(NC1=NC2=CC=C(CN3CCC(C(C)(O)C)CC3)C=C2N1[C@H]4CC[C@@H](C(NC(C)C)=O)CC4)C5=CC=C(F)C=C5
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Chemical Name4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.
2. Iams WT, et al. Cancer J. 2015 Sep-Oct;21(5):378-82.
3. Khotskaya YB, et al. Pharmacol Ther. 2017 May;173:58-66.
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