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PF-06273340
CAS No. 1402438-74-7
PF-06273340( PF06273340 | PF6273340 )
Catalog No. M11678 CAS No. 1402438-74-7
PF-06273340 is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 133 | Get Quote |
|
| 5MG | 179 | Get Quote |
|
| 10MG | 430 | Get Quote |
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| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePF-06273340
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NoteResearch use only, not for human use.
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Brief DescriptionPF-06273340 is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively.
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DescriptionPF-06273340 is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively; displays selectivity over a panel of ion channels, receptors and other enzymes; exhibits in vivo efficacy in a rodent model of inflammatory pain.Pain Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsPF06273340 | PF6273340
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PathwayTyrosine Kinase
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TargetTrk Receptor
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RecptorTrk Receptor
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number1402438-74-7
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Formula Weight479.93
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Molecular FormulaC23H22ClN7O3
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Purity>98% (HPLC)
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Solubility——
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SMILESNC1=NC=C2C(N(C(C)(C)CO)C=C2C(C3=CN=CC(NC(CC4=CC=C(Cl)C=N4)=O)=C3)=O)=N1
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Chemical NameN-(5-(2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Skerratt SE, et al. J Med Chem. 2016 Nov 23;59(22):10084-10099.
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