Lycorine

Research use only, not for human use.

Lycorine inhibits?protein synthesis and may inhibit?ascorbic acid?biosynthesis, although studies on the latter are controversial and inconclusive.

Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer. It is a natural alkaloid extracted from the Amaryllidaceae plant family.

Cell Viability Assay Cell Line:HL-7702/SRE-Luc cells Concentration:16 hours Incubation Time:5 μM; 10 μM; 20 μM; 40 μM Result:Had no cytotoxicity on HL-7702 cells.Western Blot Analysis Cell Line:HL-7702/SRE-Luc cells Concentration:2 hours, 4 hours, 8 hours, 12 hours, 16 hours Incubation Time:10 μM; 20 μM Result:Decreased p-SREBF1, m-SREBF1, p-SREBF2 and p-SREBF1 protein expression.RT-PCR Cell Line:C8161 cells Concentration:0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM Incubation Time:48 hours Result:Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells.

Animal Model:High-fat diet (HFD)-fed C57BL/6J mice Dosage:15 mg/kg, 30 mg/kg Administration:Oral chow; once daily Result:Ameliorated high-fat diet-induced hyperlipidemia, hepatic steatosis, and insulin resistance in mice.

Lycorine | Galanthidine | NSC-401360 | NSC401360

Endocrinology/Hormones

ATPase

Others

Others-Field

——

476-28-8

287.31

C16H17NO4

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (87.01 mM)

C1CN2Cc3cc4c(cc3[C@H]3[C@H]2C1=C[C@@H]([C@H]3O)O)OCO4

(1S,2S,3a1S,12bS)-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol

(-20℃)

With Ice Pack

≥ 2 years