Lycorine

CAS No. 476-28-8

Lycorine( Lycorine | Galanthidine | NSC-401360 | NSC401360 )

Catalog No. M18593 CAS No. 476-28-8

Lycorine inhibits?protein synthesis and may inhibit?ascorbic acid?biosynthesis, although studies on the latter are controversial and inconclusive.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 27 In Stock
25MG 43 In Stock
50MG 61 In Stock
100MG 98 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    Lycorine
  • Note
    Research use only, not for human use.
  • Brief Description
    Lycorine inhibits?protein synthesis and may inhibit?ascorbic acid?biosynthesis, although studies on the latter are controversial and inconclusive.
  • Description
    Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer. It is a natural alkaloid extracted from the Amaryllidaceae plant family.
  • In Vitro
    Cell Viability Assay Cell Line:HL-7702/SRE-Luc cells Concentration:16 hours Incubation Time:5 μM; 10 μM; 20 μM; 40 μM Result:Had no cytotoxicity on HL-7702 cells.Western Blot Analysis Cell Line:HL-7702/SRE-Luc cells Concentration:2 hours, 4 hours, 8 hours, 12 hours, 16 hours Incubation Time:10 μM; 20 μM Result:Decreased p-SREBF1, m-SREBF1, p-SREBF2 and p-SREBF1 protein expression.RT-PCR Cell Line:C8161 cells Concentration:0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM Incubation Time:48 hours Result:Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells.
  • In Vivo
    Animal Model:High-fat diet (HFD)-fed C57BL/6J mice Dosage:15 mg/kg, 30 mg/kg Administration:Oral chow; once daily Result:Ameliorated high-fat diet-induced hyperlipidemia, hepatic steatosis, and insulin resistance in mice.
  • Synonyms
    Lycorine | Galanthidine | NSC-401360 | NSC401360
  • Pathway
    Endocrinology/Hormones
  • Target
    ATPase
  • Recptor
    Others
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    476-28-8
  • Formula Weight
    287.31
  • Molecular Formula
    C16H17NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (87.01 mM)
  • SMILES
    C1CN2Cc3cc4c(cc3[C@H]3[C@H]2C1=C[C@@H]([C@H]3O)O)OCO4
  • Chemical Name
    (1S,2S,3a1S,12bS)-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Vrijsen R. Biol. Chem. 1986, 261 (2): 505–7.
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