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Lu-28-179
CAS No. 224177-60-0
Lu-28-179( —— )
Catalog No. M13593 CAS No. 224177-60-0
Siramesine(Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 72 | In Stock |
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| 5MG | 102 | In Stock |
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| 10MG | 165 | In Stock |
|
| 25MG | 335 | In Stock |
|
| 50MG | 500 | In Stock |
|
| 100MG | 705 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLu-28-179
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NoteResearch use only, not for human use.
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Brief DescriptionSiramesine(Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.
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DescriptionSiramesine(Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.
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In VitroSiramesine hydrochloride displays the binding affinities: IC50 (sigma 1)=17 nM, IC50 (sigma 2)=0.12 nM, IC50 (5-HT1A)=21000 nM, IC50 (5-HT1A)=2000 nM, IC50 (D2)=800 nM, IC50 (alpha 1)=330 nM. Siramesine (0-50μM; 8 hours) hydrochloride induces cell death in various cell lines (HaCaT, Hsc-4, HeLa and MCF-7, neuroblastoma cell line SH-SY5Y and glioblastoma cell line U-87MG).Siramesine (0-40 μM; 2-48 hours) hydrochloride activates caspases in HaCaT and in U-87MG cells.
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetSigma receptor
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Recptorlysosome-destabilizing agent| σ2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number224177-60-0
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Formula Weight491.04
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Molecular FormulaC30H32ClFN2O
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESCl.FC1=CC=C(C=C1)N1C=C(CCCCN2CCC3(CC2)OCC2=CC=CC=C32)C2=CC=CC=C12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cesen MH, et al. Cell Death Dis. 2013 Oct 3;4:e818.
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