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LY294002

CAS No. 154447-36-6

LY294002 ( NSC 697286;SF 1101;LY 294002;LY-294002 )

Catalog No. M12191 CAS No. 154447-36-6

A classic, broad-spectrum PI3K inhibitor with IC50 of 0.5/0.57/0.97 uM for PI3Kα/δ/β, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LY294002
  • Note
    Research use only, not for human use.
  • Brief Description
    A classic, broad-spectrum PI3K inhibitor with IC50 of 0.5/0.57/0.97 uM for PI3Kα/δ/β, respectively.
  • Description
    A classic, broad-spectrum PI3K inhibitor with IC50 of 0.5/0.57/0.97 uM for PI3Kα/δ/β, respectively; completely and specifically abolishes PI3K activity (IC50=1.4 uM), but does not inhibit PI4K or other lipid kinases; demonstrates growth-inhibitory and apoptosis-inducing effect in colon cancer cell lines, with decreased phosphorylated Akt Ser(473); suppresses tumor growth in mouse xenografts; also is a potent inhibitor of CK2 with IC50 of 98 nM.
  • Synonyms
    NSC 697286;SF 1101;LY 294002;LY-294002
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    p110α;p110β;p110δ;DNA-PK
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    154447-36-6
  • Formula Weight
    307.34
  • Molecular Formula
    C19H17NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 14.9 mg/mL
  • SMILES
    O=C1C=C(N2CCOCC2)OC3=C(C4=CC=CC=C4)C=CC=C13
  • Chemical Name
    4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Vlahos CJ, et al. J Biol Chem. 1994 Feb 18;269(7):5241-8.
2. Cheatham B, et al. Mol Cell Biol. 1994 Jul;14(7):4902-11.
3. Semba S, et al. Clin Cancer Res. 2002 Jun;8(6):1957-63.
4. Gharbi SI, et al. Biochem J. 2007 May 15;404(1):15-21.
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