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AS-605240
CAS No. 648450-29-7
AS-605240 ( AS605240;AS 605240 )
Catalog No. M15459 CAS No. 648450-29-7
AS-605240 (AS605240) is a potent, selective, ATP-competitive, orally active PI3Kγ inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 28 | In Stock |
|
| 10MG | 47 | In Stock |
|
| 25MG | 97 | In Stock |
|
| 50MG | 187 | In Stock |
|
| 100MG | 267 | In Stock |
|
| 200MG | 374 | In Stock |
|
| 500MG | 620 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAS-605240
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NoteResearch use only, not for human use.
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Brief DescriptionAS-605240 (AS605240) is a potent, selective, ATP-competitive, orally active PI3Kγ inhibitor.
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DescriptionAS-605240 (AS605240) is a potent, selective, ATP-competitive, orally active PI3Kγ inhibitor with IC50 of 8 nM; displays 30-fold selectivity for PI3Kδ、β, 7.5-fold selectivity over PI3Kα; inhibits C5a-mediated PKB phosphorylation in RAW264 mouse macrophages (IC50=90 nM); reduces neutrophil chemotaxis in vivo and suppresses joint inflammation and damage in mouse models of RA.
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SynonymsAS605240;AS 605240
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number648450-29-7
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Formula Weight257.27
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Molecular FormulaC12H7N3O2S
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Purity>98% (HPLC)
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SolubilityDMSO: 5.8 mg/mL (Need warming)
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SMILESO=C(NC/1=O)SC1=C\C2=CC=C3N=CC=NC3=C2
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Chemical Name2,4-Thiazolidinedione, 5-(6-quinoxalinylmethylene)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Camps M, et al. Nat Med. 2005 Sep;11(9):936-43.
2. Fougerat A, et al. Circulation. 2008 Mar 11;117(10):1310-7.
3. Dutra RC, et al. Br J Pharmacol. 2011 May;163(2):358-74.
4. Kobayashi N, et al. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5753-8.
2. Fougerat A, et al. Circulation. 2008 Mar 11;117(10):1310-7.
3. Dutra RC, et al. Br J Pharmacol. 2011 May;163(2):358-74.
4. Kobayashi N, et al. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5753-8.
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