Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - GlyT - LY2365109 hydrochloride

LY2365109 hydrochloride

CAS No. 1779796-27-8

LY2365109 hydrochloride( —— )

Catalog No. M26285 CAS No. 1779796-27-8

LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 43 Get Quote
5MG 72 Get Quote
10MG 115 Get Quote
25MG 222 Get Quote
50MG 335 Get Quote
100MG 484 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    LY2365109 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.
  • Description
    LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.(In Vivo):LY2365109 hydrochloride increases seizure thresholds in mice.LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine.
  • In Vitro
    ——
  • In Vivo
    LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine.LY2365109 hydrochloride increases seizure thresholds in mice. Animal Model:Male Sprague-Dawley rats (250-300 g)Dosage:0.3 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg, 30 mg/kg Administration:Oral administrationResult:Produced dose-dependent elevations in CSF levels of glycine measured 1 h after dosing.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    GlyT
  • Recptor
    Ketohexokinase (KHK)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1779796-27-8
  • Formula Weight
    421.91
  • Molecular Formula
    C22H28ClNO5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 31 mg/mL (73.48 mM)
  • SMILES
    O=C(O)CN(CCOC1=CC=C(C2=CC=C(OCO3)C3=C2)C=C1C(C)(C)C)C.Cl[H]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • PF-03463275

    PF-03463275 (PF 3463275) ia an orally bioavailable, centrally penetrant, potent, reversible, selective, and competitive inhibitor of the human GlyT1 transporter with Ki of 13 nM.

  • Opiranserin

    Opiranserin (VVZ-149, VVZ-000149) is a?potent, selective, mixed glycine GlyT2 transporter blocker (IC50= 0.86 uM).

  • Bitopertin

    A potent and selective GlyT1 inhibitor with EC50 of 30 nM; no activity for GlyT2, hERG, CYP450 enzymes above 10 uM.

Sign In Join Free