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Opiranserin
CAS No. 1441000-45-8
Opiranserin( VVZ-149 | VVZ-000149 )
Catalog No. M11871 CAS No. 1441000-45-8
Opiranserin (VVZ-149, VVZ-000149) is a potent, selective, mixed glycine GlyT2 transporter blocker (IC50= 0.86 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameOpiranserin
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NoteResearch use only, not for human use.
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Brief DescriptionOpiranserin (VVZ-149, VVZ-000149) is a potent, selective, mixed glycine GlyT2 transporter blocker (IC50= 0.86 uM).
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DescriptionOpiranserin (VVZ-149, VVZ-000149) is a potent, selective, mixed glycine GlyT2 transporter blocker (IC50= 0.86 uM), purine P2X3 receptor antagonist (IC50=0.87 uM) and serotonin 5-HT2A receptor antagonist (IC50=1.3 uM); demonstrates analgesic efficacy for postoperative pain.Pain Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsVVZ-149 | VVZ-000149
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PathwayMembrane Transporter/Ion Channel
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TargetGlyT
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RecptorGlyT
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number1441000-45-8
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Formula Weight394.512
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Molecular FormulaC21H34N2O5
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NCC1(N(C)C)CCOCC1)C2=CC(OC)=C(OCCCC)C(OC)=C2
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Chemical NameBenzamide, 4-butoxy-N-[[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl]-3,5-dimethoxy-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nedeljkovic SS, et al. BMJ Open. 2017 Feb 17;7(2):e011035.
2. Oh J, et al. J Clin Pharmacol. 2018 Jan;58(1):64-73.
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