Cart
sales@molnova.com
PF-03463275
CAS No. 1173177-11-1
PF-03463275( PF 3463275 )
Catalog No. M10582 CAS No. 1173177-11-1
PF-03463275 (PF 3463275) ia an orally bioavailable, centrally penetrant, potent, reversible, selective, and competitive inhibitor of the human GlyT1 transporter with Ki of 13 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePF-03463275
-
NoteResearch use only, not for human use.
-
Brief DescriptionPF-03463275 (PF 3463275) ia an orally bioavailable, centrally penetrant, potent, reversible, selective, and competitive inhibitor of the human GlyT1 transporter with Ki of 13 nM.
-
DescriptionPF-03463275 (PF 3463275) ia an orally bioavailable, centrally penetrant, potent, reversible, selective, and competitive inhibitor of the human GlyT1 transporter with Ki of 13 nM; shows no significant affinity for GlyT2 (Ki >1 mM); is under investigation for the treatment of schizophrenia.Schizophrenia Phase 2 Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsPF 3463275
-
PathwayMembrane Transporter/Ion Channel
-
TargetGlyT
-
RecptorGlyT
-
Research AreaNeurological Disease
-
IndicationSchizophrenia
Chemical Information
-
CAS Number1173177-11-1
-
Formula Weight376.86
-
Molecular FormulaC19H22ClFN4O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(C1=CN(C)C=N1)N(CC2=CC=C(F)C(Cl)=C2)CC3[C@@]4([H])CN(C)C[C@@]34[H]
-
Chemical NameN-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl]methyl]imidazole-4-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Roberts BM, et al. Neuroreport. 2010 Mar 31;21(5):390-4.
2. Liu CN, et al. Cutan Ocul Toxicol. 2014 Sep;33(3):206-11.
molnova catalog
related products
-
AMG 747
A nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia.
-
ALX-1393
ALX-1393 is a selective GlyT2 inhibitor that effectively reduces neuronal action potential activity in a concentration-dependent manner and inhibits the activity of spontaneous networks by inducing glycinergic tetanic currents in the abdominal horn of the spinal cord.
-
Org 25543 hydrochlor...
Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells.
