LX2761( LX 2761 | LX-2761 )

Catalog No. M12329 CAS No. 1610954-97-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LX2761
Note

Research use only, not for human use.
Brief Description

A potent, locally acting and orally bioavailable SGLT1 inhibitor that inhibits human SGLT1- and SGLT2-mediated glucose uptake with IC50 of 2.2 nM and 2.7 nM, respectively.
Description

A potent, locally acting and orally bioavailable SGLT1 inhibitor that inhibits human SGLT1- and SGLT2-mediated glucose uptake with IC50 of 2.2 nM and 2.7 nM, respectively, restricted to the intestinal lumen; synergistically increases active GLP-1 levels combined with sitagliptin, lowers postprandial glucose, fasting glucose, and hemoglobin A1C, and increased plasma total GLP-1 in mice; delays intestinal glucose absorption in vivo to improve glycemic control.Diabetes Phase 1 Clinical.
In Vitro

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In Vivo

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Synonyms

LX 2761 | LX-2761
Pathway

GPCR/G Protein
Target

SGLT
Recptor

SGLT
Research Area

Metabolic Disease
Indication

Diabetes

CAS Number

1610954-97-6
Formula Weight

601.803
Molecular Formula

C32H47N3O6S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NC(C)(C)C(NCCN(C)C)=O)CCCC1=CC=C(CC2=CC([C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](SC)O3)=CC=C2C)C=C1
Chemical Name

N-(1-((2-(Dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-butanamide

1. Goodwin NC, et al. J Med Chem. 2017 Jan 26;60(2):710-721. 2. Powell DR, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):85-97.

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