LLS30 ( LLS-30 )

Catalog No. M13409 CAS No. 2138367-58-3

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Datasheet

HNMR

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Product Name

LLS30
Note

Research use only, not for human use.
Brief Description

LLS30 is a potent, allosteric Galectin-1 (Gal-1) inhibitor.
Description

LLS30 is a potent, allosteric Galectin-1 (Gal-1) inhibitor, inhibits AR negative cells PC3, DU145, and AR positive cells, 22RV1 and CWR-R1 cells with IC50 of 10.4 μM, 5.3 μM, 3.3 μM and 5.9 μM, respectively; decreases Gal-1 binding affinity to its binding partners; showes in vivo efficacy in both AR positive and AR negative xenograft models; not only can potentiate the anti-tumor effect of docetaxel to cause complete regression of tumors, but also effectively inhibit the invasion and metastasis of PCa cells in vivo.
Synonyms

LLS-30
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Galectin
Recptor

Galectin
Research Area

——
Indication

——

CAS Number

2138367-58-3
Formula Weight

701.47
Molecular Formula

C34H33Cl4N5O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N)CC(C1=CC=C2N(CC3=CC=C(Cl)C(Cl)=C3)C(C4=CC=C(N(CCO)CCO)C=C4)=NC2=C1)NCC5=CC=C(Cl)C(Cl)=C5
Chemical Name

3-(2-(4-(bis(2-hydroxyethyl)amino)phenyl)-1-(3,4-dichlorobenzyl)-1H-benzo[d]imidazol-5-yl)-3-((3,4-dichlorobenzyl)amino)propanamide

1. Shih TC, et al. Clin Cancer Res. 2018 Apr 17. pii: clincanres.0157.2018.

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