GB1107
CAS No. 1978336-61-6
GB1107 ( GB-1107;GB 1107 )
Catalog No. M13093 CAS No. 1978336-61-6
GB1107 (GB-1107, GB 1107) is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with Kd of 37 nM (human Galectin-3).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 115 | Get Quote |
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10MG | 170 | Get Quote |
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25MG | 284 | Get Quote |
|
50MG | 421 | Get Quote |
|
100MG | 617 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameGB1107
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NoteResearch use only, not for human use.
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Brief DescriptionGB1107 (GB-1107, GB 1107) is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with Kd of 37 nM (human Galectin-3).
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DescriptionGB1107 (GB-1107, GB 1107) is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with Kd of 37 nM (human Galectin-3); displays >100-fold lower affinity for most of the tested human galectins, and 20 and 4-fold lower affinity for galectin-2 and the C-terminal CRD of galectin-4, respectively; prevents human lung adenocarcinoma growth in vivo, increases tumor M1 macrophage polarization and CD8+ T cell infiltration; GB1107 also can potentiate the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-γ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules.
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SynonymsGB-1107;GB 1107
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetGalectin
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RecptorGalectin
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Research Area——
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Indication——
Chemical Information
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CAS Number1978336-61-6
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Formula Weight522.32
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Molecular FormulaC20H16Cl2F3N3O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESO[C@H]([C@@H](N1N=NC(C2=CC(F)=C(F)C(F)=C2)=C1)[C@H]([C@@H](CO)O3)O)[C@H]3SC4=CC=C(Cl)C(Cl)=C4
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Chemical Name3,4-dichlorophenyl 3-deoxy-3-[4(3,4,5-trifluorophenyl)-1H-1,2,3- triazol-1-yl]-1-thio-α-D-galactopyranoside
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Vuong L, et al. Cancer Res. 2019 Jan, doi: 10.1158/0008-5472.CAN-18-2244.
2. Zetterberg FR, et al. ChemMedChem. 2018 Jan 22;13(2):133-137.
2. Zetterberg FR, et al. ChemMedChem. 2018 Jan 22;13(2):133-137.
molnova catalog
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