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L189
CAS No. 64232-83-3
L189 ( L189; L 189; L-189 )
Catalog No. M18946 CAS No. 64232-83-3
L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
|
| 5MG | 53 | In Stock |
|
| 10MG | 82 | In Stock |
|
| 25MG | 176 | In Stock |
|
| 50MG | 309 | In Stock |
|
| 100MG | 432 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameL189
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NoteResearch use only, not for human use.
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Brief DescriptionL189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
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DescriptionL189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. L189 will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents.
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SynonymsL189; L 189; L-189
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PathwayOthers
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TargetOther Targets
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RecptorDNA Ligase I; DNA Ligase III; DNA Ligase IV
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number64232-83-3
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Formula Weight246.29
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Molecular FormulaC11H10N4OS
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Purity98%
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SolubilityDMSO : ≥ 33 mg/mL; 33.99 mM
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SMILESNc1[nH]c(=S)[nH]c(=O)c1\N=C\c1ccccc1
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Chemical Name(E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xi Chen, et al. Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair. Cancer Res 2008; 68: (9). May 1, 2008.
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