L189 ( L189; L 189; L-189 )

Catalog No. M18946 CAS No. 64232-83-3

L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).

Purity : 98%

COA

Datasheet

HNMR

HPLC

MSDS

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5MG	53	In Stock
10MG	82	In Stock
25MG	176	In Stock
50MG	309	In Stock
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Biological Information

Product Name

L189
Note

Research use only, not for human use.
Brief Description

L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
Description

L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. L189 will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents.
Synonyms

L189; L 189; L-189
Pathway

Others
Target

Other Targets
Recptor

DNA Ligase I; DNA Ligase III; DNA Ligase IV
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

64232-83-3
Formula Weight

246.29
Molecular Formula

C11H10N4OS
Purity

98%
Solubility

DMSO : ≥ 33 mg/mL; 33.99 mM
SMILES

Nc1[nH]c(=S)[nH]c(=O)c1\N=C\c1ccccc1
Chemical Name

(E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Xi Chen, et al. Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair. Cancer Res 2008; 68: (9). May 1, 2008.

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