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L-Phenylalanine

CAS No. 63-91-2

L-Phenylalanine( —— )

Catalog No. M15427 CAS No. 63-91-2

L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    L-Phenylalanine
  • Note
    Research use only, not for human use.
  • Brief Description
    L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM.
  • Description
    L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM. IC50 Value: 980 nM Target: Calcium Channel L-Phenylalanine (LPA) is an electrically neutral amino acid, one of the twenty common amino acids used to biochemically form proteins.(In Vitro):DAHP synthetase (DS) and chorismate mutase/prephenate dehydratase (CM/PD) are key enzymes in the L-Phenylalanine biosynthesis pathway. DS is sensitive to feedback inhibition by tyrosine, and CM/PD is subject to feedback inhibition by L-Phenylalanine. L-Phenylalanine attenuates non-NMDA receptor function in cultured neurons with an IC50 of 980 μM.(In Vivo):The effects of L-Phenylalanine on NMDA-activated currents (INMDA) are studied in cultured hippocampal neurons from newborn rats using the patch-clamp technique. L-Phenylalanine specifically and reversibly attenuates INMDA in a concentration-dependent manner (IC50 of 1.71 mM). L-Phenylalanine inhibits specifically NMDAR current in hippocampal neurons by competing for the glycine-binding site.
  • In Vitro
    DAHP synthetase (DS) and chorismate mutase/prephenate dehydratase (CM/PD) are key enzymes in the L-Phenylalanine biosynthesis pathway. DS is sensitive to feedback inhibition by tyrosine, and CM/PD is subject to feedback inhibition by L-Phenylalanine.L-Phenylalanine attenuates non-NMDA receptor function in cultured neurons with an IC50 of 980 μM.
  • In Vivo
    The effects of L-Phenylalanine on NMDA-activated currents (INMDA) are studied in cultured hippocampal neurons from newborn rats using the patch-clamp technique. L-Phenylalanine specifically and reversibly attenuates INMDA in a concentration-dependent manner (IC50 of 1.71 mM). L-Phenylalanine inhibits specifically NMDAR current in hippocampal neurons by competing for the glycine-binding site.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    α2δ calcium channels
  • Research Area
    Metabolic Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    63-91-2
  • Formula Weight
    165.19
  • Molecular Formula
    C9H11NO2
  • Purity
    >98% (HPLC)
  • Solubility
    H2O: ≥ 46 mg/Ml
  • SMILES
    N[C@@H](CC1=CC=CC=C1)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mortell, K.H., et al., Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett, 2006. 16(5): p. 1138-41. 2. Glushakov, A.V., et al., Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria. Mol Psychiatry, 2002. 7(4): p. 359-67. 3. Glushakov, A.V., et al., L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses. J Neurosci Res, 2003. 72(1): p. 116-24. 4. Glushakov, A.V., et al., Long-term changes in glutamatergic synaptic transmission in phenylketonuria. Brain, 2005. 128(Pt 2): p. 300-7. 5. Moller, H.E., et al., Brain imaging and proton magnetic resonance spectroscopy in patients with phenylketonuria. Pediatrics, 2003. 112(6 Pt 2): p. 1580-3.
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