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TTA-A2
CAS No. 953778-63-7
TTA-A2( —— )
Catalog No. M25008 CAS No. 953778-63-7
TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 282 | In Stock |
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| 10MG | 439 | In Stock |
|
| 25MG | 707 | In Stock |
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| 50MG | 1008 | In Stock |
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| 100MG | 1332 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTTA-A2
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NoteResearch use only, not for human use.
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Brief DescriptionTTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating.?
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DescriptionTTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating.?TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels with IC50 values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials.?TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy.
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In Vitro——
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In VivoAnimal Model:Wild-type and double Cav3.1/Cav3.3 knockout C57BL6/Sv129 background mices Dosage:10?mg/kg Administration:Oral gavage; 10?mg/kg; once daily; 5 days Result:Blocked active wake and promotes slow-wave sleep in wild-type mice but not mutant mice.
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Synonyms——
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCav3.1 (a1G)|Cav3.2 (a1H)
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Research Area——
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Indication——
Chemical Information
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CAS Number953778-63-7
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Formula Weight378.4
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Molecular FormulaC20H21F3N2O2
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESC[C@H](C1=NC=C(C=C1)OCC(F)(F)F)NC(=O)CC2=CC=C(C=C2)C3CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Richard L Kraus, et al.In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice. J Pharmacol Exp Ther. 2010 Nov;335(2):409-17.
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