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FPL64176
CAS No. 120934-96-5
FPL64176( ARC-64176 | FPL-64176 )
Catalog No. M10781 CAS No. 120934-96-5
FPL64176 (ARC-64176) is a potent L-type Ca++ channel activator with EC50 of 16 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 72 | Get Quote |
|
| 10MG | 115 | Get Quote |
|
| 25MG | 250 | Get Quote |
|
| 50MG | 462 | Get Quote |
|
| 100MG | 672 | Get Quote |
|
| 500MG | 1404 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameFPL64176
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NoteResearch use only, not for human use.
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Brief DescriptionFPL64176 (ARC-64176) is a potent L-type Ca++ channel activator with EC50 of 16 nM.
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DescriptionFPL64176 (ARC-64176) is a potent L-type Ca++ channel activator with EC50 of 16 nM; prolongs action potential duration and enhances contractility in guinea pig papillary muscle, induces contractile response with EC50 of 0.2 uM; produces biexponential tail current decays at -50 mV with fast and slow time constants of 4.30 +/- 0.30 and 44.52 +/- 4.56 msec, respectively; produces large increases in cardiac contractile force and diastolic blood pressure in anesthetized dogs (100 mg/kg, i.v.). Heart Failure Discontinued.
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In Vitro——
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In Vivo——
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SynonymsARC-64176 | FPL-64176
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number120934-96-5
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Formula Weight347.414
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Molecular FormulaC22H21NO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (287.84 mM)
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SMILESO=C(C1=C(C)NC(C)=C1C(C2=CC=CC=C2CC3=CC=CC=C3)=O)OC
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Chemical Name2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Baxter AJ, et al. J Med Chem. 1993 Sep 17;36(19):2739-44.
2. Rampe D, et al. J Pharmacol Exp Ther. 1993 Jun;265(3):1125-30.
3. Zheng W, et al. Mol Pharmacol. 1991 Nov;40(5):734-41.
4. Liu L, et al. Neuropharmacology. 2003 Aug;45(2):281-92.
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