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L-168049

CAS No. 191034-25-0

L-168049 ( L-168,049 )

Catalog No. M27645 CAS No. 191034-25-0

human glucagon receptor (hGR) antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 102 Get Quote
10MG 170 Get Quote
25MG 357 Get Quote
50MG 530 Get Quote
100MG 759 Get Quote
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Biological Information

  • Product Name
    L-168049
  • Note
    Research use only, not for human use.
  • Brief Description
    human glucagon receptor (hGR) antagonist.
  • Description
    human glucagon receptor (hGR) antagonist(In Vitro):In Chinese hamster ovary cells expressing the human glucagon receptor, L-168049 increases the apparent EC50 of glucagon-stimulated adenylate cyclase and decreases maximal glucagon stimulation with a Kb of 25 nM. L-168049 blocks glucagon-stimulated cAMP formation in mouse liver membrane and inhibits glucagon (100 pM)-stimulated cAMP synthesis in CHO cells expressing the human glucagon receptor with IC50 of 41 nM .(In Vivo):In the liver of L-G6pc-/- mice, L-168049 (50 mg/kg body; p.o.) reduces Pck1 mRNA expression by half within 6 hours. L-168049 prevents the increase in G6pc expression in the kidney and gut .
  • Synonyms
    L-168,049
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    191034-25-0
  • Formula Weight
    467.8
  • Molecular Formula
    C24H20BrClN2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCCOc1ccc(Br)cc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.García González M, et al. [Droxicam-induced hepatitis. Description of 3 new cases and review of the literature]. Rev Clin Esp. 1994 Mar;194(3):170-2. Review. Spanish.
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