Koumine ( Koumine )

Catalog No. M17971 CAS No. 1358-76-5

COA

Datasheet

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Product Name

Koumine
Note

Research use only, not for human use.
Brief Description

Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent.
Description

Koumine is an indole alkaloid. It reverses thermal hyperalgesia and mechanical allodynia induced by sciatic nerve chronic constriction injury (CCI) in rats in a dose-dependent manner. This effect is mediated by elevated allopregnanolone levels in the spinal cord.
Synonyms

Koumine
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Others-Field
Indication

——

CAS Number

1358-76-5
Formula Weight

306.4
Molecular Formula

C20H22N2O
Purity

98%
Solubility

DMSO : 31.25 mg/mL 101.99 mM;
SMILES

CN1CC2(C3CC4C5=NC6=CC=CC=C6C52CC1C3CO4)C=C
Chemical Name

(4aR,6R,11cS)-2-methyl-11c-vinyl-1,2,3,4,4a,5,6,11c-octahydro-6,4-(epoxymethano)-3,11b-methanopyrido[4,3-c]carbazole