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UU-T03

CAS No. 1586007-00-2

UU-T03( UU-T 03 )

Catalog No. M12263 CAS No. 1586007-00-2

UU-T03 is the ethyl ester derivative of UU-T02, which is a potent, selective inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    UU-T03
  • Note
    Research use only, not for human use.
  • Brief Description
    UU-T03 is the ethyl ester derivative of UU-T02, which is a potent, selective inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM.
  • Description
    UU-T03 is the ethyl ester derivative of UU-T02, which is a potent, selective inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM; exhibits growth inhibition of SW480 cells with IC50 of 10.77 uM; downregulates the transcription of AXIN2, LGR5, cyclin D1, and c-Myc in dose-dependent manners in SW480 cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    UU-T 03
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Beta-catenin
  • Recptor
    Beta-catenin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1586007-00-2
  • Formula Weight
    721.204
  • Molecular Formula
    C37H41ClN4O9
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(OCC)CC[C@@H](C(OC)=O)NC([C@@H](NC([C@@H](NC(CC(N1)=CC2=C1C=CC(Cl)=C2)=O)CC3=CC=C4C=CC=CC4=C3)=O)CC(OCC)=O)=O
  • Chemical Name
    5-ethyl 1-methyl ((S)-2-((S)-2-(2-(5-chloro-1H-indol-2-yl)acetamido)-3-(naphthalen-2-yl)propanamido)-4-ethoxy-4-oxobutanoyl)-L-glutamate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Huang Z, et al. ACS Chem Biol. 2014 Jan 17;9(1):193-201.
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