KU675

Research use only, not for human use.

A novel, second-generation C-terminal Hsp90 inhibitor with Kd of 191 and 726 uM for Hsp90α and Hsp90β, respectively.

A novel, second-generation C-terminal Hsp90 inhibitor with Kd of 191 and 726 uM for Hsp90α and Hsp90β, respectively; also displays binding to Hsc70 with Kd of 76.3 uM, reduces the expression of Hsc70-specific client proteins; demonstrates antiproliferative effect against PC3MM2 cells with IC50 of 5-10 uM, for LNCap-LN3, LAPC-4, and C4-2 cells, IC50 if 1.5-2.5 uM; exhibits greater inhibition of Hsp90’s protein folding function than the N-terminal inhibitor, 17-AAG.

——

——

KU-675 | KU 675

Cytoskeleton/Cell Adhesion Molecules

HSP

HSP

——

——

1535221-75-0

455.939

C24H26ClN3O4

>98% (HPLC)

——

CC1=C(C=CC2=C1OC(=O)C(=C2)NC(=O)NC3=CC=C(C=C3)Cl)OCCC4CCCCN4

1-(4-chlorophenyl)-3-(8-methyl-2-oxo-7-(2-(piperidin-2-yl)ethoxy)-2H-chromen-3-yl)urea

(-20℃)

With Ice Pack

≥ 2 years