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KSQ-4279

CAS No. 2446480-97-1

KSQ-4279( —— )

Catalog No. M35309 CAS No. 2446480-97-1

KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP, exhibiting anticancer activity. It is utilized in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine, and pancreatic cancers.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 240 Get Quote
5MG 376 Get Quote
10MG 560 Get Quote
25MG 868 Get Quote
50MG 1178 Get Quote
100MG 1548 Get Quote
500MG Get Quote Get Quote
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Biological Information

  • Product Name
    KSQ-4279
  • Note
    Research use only, not for human use.
  • Brief Description
    KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP, exhibiting anticancer activity. It is utilized in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine, and pancreatic cancers.
  • Description
    KSQ-4279 (USP1-IN-1) is a potent, first-in-class, and highly selective USP1 inhibitor. KSQ-4279 shows anticancer effects.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP | DUB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2446480-97-1
  • Formula Weight
    534.54
  • Molecular Formula
    C27H25F3N8O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 80 mg/mL (149.66 mM; Ultrasonic )
  • SMILES
    COc1ncnc(C2CC2)c1-c1ncc2cnn(Cc3ccc(cc3)-c3nc(cn3C(C)C)C(F)(F)F)c2n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Natalie Y L Ngoi, et al. Targeting the DNA damage response beyond poly(ADP-ribose) polymerase inhibitors: novel agents and rational combinations. Curr Opin Oncol. 2022 Sep 1;34(5):559-569.?
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