GeA-69

CAS No. 2143475-98-1

GeA-69( —— )

Catalog No. M20135 CAS No. 2143475-98-1

GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 53 In Stock
10MG 87 In Stock
25MG 177 In Stock
50MG 312 In Stock
100MG 431 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    GeA-69
  • Note
    Research use only, not for human use.
  • Brief Description
    GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).
  • Description
    GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).
  • In Vitro
    GeA-69 (compound 1) (50 μM and 250 μM; pre-damage for 1 h or 0.5, 1, 2.5 min) engages PARP14 MD2 in intact cells and prevents its localisation to sites of DNA damage in U-2 OS cells. GeA-69 (25 nM-250 μM; 72 h) exhibits moderate cytotoxicity among HeLa, U-2 OS and HEK293 cells and highly cell permeable with 2 % passing paracellular and 98 % transcellular over the membrane. Cell Cytotoxicity Assay Cell Line:HeLa, U-2 OS and HEK293 cells Concentration:25 nM-250 μM Incubation Time:72 hours Result:Resulted moderate cytotoxicity against normal cells with EC50_HeLa=58 μM, EC50_U-2 OS=52 μM, EC50_HEK293=54 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP14
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2143475-98-1
  • Formula Weight
    300.36
  • Molecular Formula
    C20H16N2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 120 mg/mL (399.53 mM)
  • SMILES
    CC(=O)Nc1ccccc1-c1cccc2c3ccccc3[nH]c12
  • Chemical Name
    N-(2-(9H-carbazol-1-yl)phenyl)acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Schuller M et al. Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14. ACS Chem Biol. 2017 Nov 17;12(11):2866-2874.
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