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KNK-437

CAS No. 218924-25-5

KNK-437( KNK437 )

Catalog No. M13492 CAS No. 218924-25-5

An inhibitor of Heat shock protein (HSP) synthesis that dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in human colon carcinoma cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KNK-437
  • Note
    Research use only, not for human use.
  • Brief Description
    An inhibitor of Heat shock protein (HSP) synthesis that dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in human colon carcinoma cells.
  • Description
    An inhibitor of Heat shock protein (HSP) synthesis that dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in human colon carcinoma cells; inhibits the acquisition of thermotolerance as developed by sodium arsenite, also inhibited at mRNA levels; shows no antitumor effects and does not increase the thermosensitivity of nontolerant tumors in vivo (up to 200 mg/kg).Colon Cancer Preclinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    KNK437
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP105|HSP40|HSP72
  • Research Area
    Cancer
  • Indication
    Colon Cancer

Chemical Information

  • CAS Number
    218924-25-5
  • Formula Weight
    245.2307
  • Molecular Formula
    C13H11NO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 34 mg/mL
  • SMILES
    O=CN1C(/C(CC1)=C\C2=CC=C(OCO3)C3=C2)=O
  • Chemical Name
    1-Pyrrolidinecarboxaldehyde, 3-(1,3-benzodioxol-5-ylmethylene)-2-oxo-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yokota S, et al. Cancer Res. 2000 Jun 1;60(11):2942-8. 2. Koishi M, et al. Clin Cancer Res. 2001 Jan;7(1):215-9. 3. Guo F, et al. Cancer Res. 2005 Nov 15;65(22):10536-44.
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