KIN1148

Research use only, not for human use.

KIN1148 is a novel small-molecule adjuvant that acts through the RIG-I pathway and IRF-3 transcription factor to stimulate inN/Ate immunity and protection following viral infection.

KIN-1148 is a IRF3 agonist. IN1148 induced dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. Prime-boost immunization of mice with a suboptimal dose of a monovalent pandemic influenza split virus H1N1 A/California/07/2009 vaccine plus KIN1148 protected against a lethal challenge with mouse-adapted influenza virus (A/California/04/2009) and induced an influenza virus-specific IL-10 and Th2 response by T cells derived from lung and lung-draining lymph nodes.

KIN-1148; KIN 1148; KIN1148

Tyrosine Kinase

FLT3

Others

Inflammation/Immunology

——

1428729-56-9

361.44

C19H11N3OS2

98%

DMSO : ≥ 100 mg/mL. 276.67 mM

O=C(NC1=NC2=CC=C3C(N=CS3)=C2S1)C4=CC5=C(C=C4)C=CC=C5

N-(benzo[1,2-d:3,4-d']bis(thiazole)-2-yl)-2-naphthamide

(-20℃)

With Ice Pack

≥ 2 years