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Tandutinib

CAS No. 387867-13-2

Tandutinib ( MLN-518;MLN518;CT53518;MLN0518;MLN-0518;CT-53518 )

Catalog No. M14334 CAS No. 387867-13-2

A potent inhibitor of FLT3, Kit and PDGFR with IC50 of 0.22, 0.17 and 0.2 uM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tandutinib
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent inhibitor of FLT3, Kit and PDGFR with IC50 of 0.22, 0.17 and 0.2 uM, respectively.
  • Description
    A potent inhibitor of FLT3, Kit and PDGFR with IC50 of 0.22, 0.17 and 0.2 uM, respectively; displays 15-20-fold less potent activity against CSF-1R; inhibits IL-3-independent cell growth and FLT3-ITD autophosphorylation with IC50 of 10-100 nM, induces apoptosis and inhibits FLT3-ITD phosphorylation, cellular proliferation and signaling through MAPK and PI3K pathways; exhibits ativity in murine models of FLT3-ITD-mediated disease.Brain Cancer Phase 2 Discontinued
  • Synonyms
    MLN-518;MLN518;CT53518;MLN0518;MLN-0518;CT-53518
  • Pathway
    Tyrosine Kinase
  • Target
    FLT3
  • Recptor
    c-Kit;CSF-1R;FLT3;PDGFRβ;Src
  • Research Area
    Cancer
  • Indication
    Brain Cancer

Chemical Information

  • CAS Number
    387867-13-2
  • Formula Weight
    562.70
  • Molecular Formula
    C31H42N6O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 36 mg/mL
  • SMILES
    O=C(N1CCN(C2=C3C=C(OC)C(OCCCN4CCCCC4)=CC3=NC=N2)CC1)NC5=CC=C(OC(C)C)C=C5
  • Chemical Name
    1-Piperazinecarboxamide, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kelly LM, et al. Cancer Cell. 2002 Jun;1(5):421-32.
2. Pandey A, et al. J Med Chem. 2002 Aug 15;45(17):3772-93.
3. Griswold IJ, et al. Blood. 2004 Nov 1;104(9):2912-8.
4. Clark JJ, et al. Blood. 2004 Nov 1;104(9):2867-72.
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